An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is
a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal …

Pre-Bötzinger complex (pre-BötC) network activity within the mammalian brainstem controls
the inspiratory phase of the respiratory rhythm. While bursting in pre-BötC neurons during …

Many types of neurons and excitable cells could intrinsically generate bursting activity, even
in an isolated case, which plays a vital role in neuronal signaling and synaptic plasticity. In …

A central issue in the study of the neural generation of respiratory rhythms is the role of the
intrinsic pacemaking capabilities that some respiratory neurons exhibit. The debate on this …

Intensive computational and theoretical work has led to the development of multiple
mathematical models for bursting in respiratory neurons in the pre-Bötzinger Complex (pre …

Hiccups (singultus) comprise repeated episodes of sharp, large-volume inspiration followed
by glottic closure, interspersed among normal inspiration. Hiccupping causes involuntary …

Recordings from pre-Bötzinger complex neurons responsible for the inspiratory phase of the
respiratory rhythm reveal a ramping burst pattern, starting around the time that the transition …

Neurons in the brain are known to exhibit diverse bursting patterns. In this work, which
combines three projects, we develop and analyze computational models to study various …

How breathing is generated by the preBötzinger Complex (preBötC) remains divided
between two ideological frameworks, and the persistent sodium current (I NaP) lies at the …

The cholinergic system plays an essential role in central respiratory control, but the
underlying mechanisms remain elusive. We used whole-cell recordings in brainstem slices …