[HTML][HTML] An updated review summarizing the anticancer efficacy of melittin from bee venom in several models of human cancers

P Pandey, F Khan, MA Khan, R Kumar, TK Upadhyay - Nutrients, 2023 - mdpi.com
Apitherapy (using bee products) has gained broad recognition in cancer therapeutics
globally. Honeybee venom has a broad range of biological potential, and its utilization is …

[HTML][HTML] Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective

P Shi, S Xie, J Yang, Y Zhang, S Han, S Su… - Frontiers in …, 2022 - frontiersin.org
Bee venom (BV), a type of defensive venom, has been confirmed to have favorable
activities, such as anti-tumor, neuroprotective, anti-inflammatory, analgesic, anti-infectivity …

[HTML][HTML] Pharmacological properties and therapeutic potential of honey bee venom

A Ullah, FM Aldakheel, SI Anjum, G Raza… - Saudi Pharmaceutical …, 2023 - Elsevier
Honey bee venom (BV) is a valuable product, and has a wide range of biological effects,
and its use is rapidly increasing in apitherapy. Therefore, the current study, we reviewed the …

[HTML][HTML] Can bee venom be used as anticancer agent in modern medicine?

A Małek, M Strzemski, J Kurzepa, J Kurzepa - Cancers, 2023 - mdpi.com
Simple Summary The beneficial effects of natural substances that have been used in
medicine for many years require both scientific confirmation and recognition of the …

[HTML][HTML] Beehive products as antibacterial agents: A review

RA Nader, R Mackieh, R Wehbe, D El Obeid… - Antibiotics, 2021 - mdpi.com
Honeybees are one of the most marvelous and economically beneficial insects. As
pollinators, they play a vital role in every aspect of the ecosystem. Beehive products have …

[HTML][HTML] The current landscape of the antimicrobial peptide melittin and its therapeutic potential

HQ Zhang, C Sun, N Xu, W Liu - Frontiers in Immunology, 2024 - frontiersin.org
Melittin, a main component of bee venom, is a cationic amphiphilic peptide with a linear α-
helix structure. It has been reported that melittin can exert pharmacological effects, such as …

[HTML][HTML] Evaluation of anti-cancer effects of carnosine and melittin-loaded niosomes in MCF-7 and MDA-MB-231 breast cancer cells

MMA Hussein, A Abdelfattah-Hassan… - Frontiers in …, 2023 - frontiersin.org
Background: We investigated the anti-cancer effect of carnosine-loaded niosomes (Car-NIO)
and melittin-loaded niosomes (Mel-NIO) with olaparib in breast cancer cell lines (MCF-7 and …

[HTML][HTML] Bee Venom and Its Two Main Components—Melittin and Phospholipase A2—As Promising Antiviral Drug Candidates

C Yaacoub, R Wehbe, R Roufayel, Z Fajloun… - Pathogens, 2023 - mdpi.com
Viruses are known to infect most types of organisms. In humans, they can cause several
diseases that range from mild to severe. Although many antiviral therapies have been …

[HTML][HTML] Bee venom-loaded EGFR-targeting peptide-coupled chitosan nanoparticles for effective therapy of hepatocellular carcinoma by inhibiting EGFR-mediated …

S Abdulmalek, N Mostafa, M Gomaa, M El‑Kersh… - PLoS …, 2022 - journals.plos.org
Hepatocellular carcinoma (HCC) is one of the world's most risky diseases due to the lack of
clear and cost-effective therapeutic targets. Currently, the toxicity of conventional …

[HTML][HTML] Melittin inhibits the proliferation migration and invasion of HCC cells by regulating ADAMTS9-AS2 demethylation

C Lv, J Chen, F Huang, F Fang, B Li - Toxicon, 2023 - Elsevier
Background Melittin (MEL) has been reported to exhibit anti-cancer effects in vitro against
several types of cancer. Long non-coding RNA (lncRNA) ADAMTS9-AS2 can be used as a …