Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

Expression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in
thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β …

Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

To test the feasibility of using the survivin promoter to induce specific expression of
sodium/iodide symporter (NIS) in cancer cell lines and tumors for targeted use of …

Since the specific accumulation of iodide in thyroid was found in 1915, radioiodine has been
widely applied to diagnose and treat thyroid cancer. Iodide uptake occurs across the …

Leiomyosarcoma (LMS) has been challenging to diagnose because of limitations in clinical
and radiographic predictors, as well as the lack of reliable serum or urinary biomarkers. Most …

Purpose: Oncolytic adenoviruses are promising tools for cancer therapy. Although several
clinical reports have indicated both safety and promising antitumor capabilities for these …

Small-interference RNAs (siRNAs) are short, double-strand RNA molecules that target
specific messenger RNAs for degradation via the process termed RNA interference. The …

Context: Telomerase promoters (hTERT and hTR) are useful for transcriptional targeting in
gene therapy models of cancer. Telomerase-driven expression of the sodium iodide …

Here we reported the radiolabeling and evaluation of a novel 131 I-radiolabeled quercetin
for the treatment of dedifferentiated thyroid cancers. The human thyroid cancer cell lines …