Snakebite envenoming is a neglected tropical disease that kills> 100,000 people and
maims> 400,000 people every year. Impoverished populations living in the rural tropics are …

The phage display technology is based on the presentation of peptide sequences on the
surface of virions of bacteriophages. Its development led to creation of sophisticated systems …

Snakebite envenoming is a major global public health concern for which improved therapies
are urgently needed. The antigenic diversity present in snake venom toxins from various …

Here, we provide a protocol to generate synthetic nanobodies, known as sybodies, against
any purified protein or protein complex within a 3-week period. Unlike methods that require …

Centralized facilities for genetic engineering, or “biofoundries”, offer the potential to design
organisms to address emerging needs in medicine, agriculture, industry, and defense. The …

Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Abstract The World Health Organization recently listed snakebite envenoming as a
Neglected Tropical Disease, proposing strategies to significantly reduce the global burden …

Snakebite envenoming is a significant global health challenge, and for over a century,
traditional plasma-derived antivenoms from hyperimmunized animals have been the primary …

Snake envenoming is a globally neglected public health problem. Antivenoms produced
using animal hyperimmune plasma remain the standard therapy for snakebites. Although …