RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Protein–RNA and protein–DNA interactions play fundamental roles in many biological
processes. A detailed understanding of these interactions requires knowledge about protein …

Abstract tRNA are post-transcriptionally modified by chemical modifications that affect all
aspects of tRNA biology. An increasing number of mutations underlying human genetic …

Sulfuration of uridine 8, in bacterial and archaeal tRNAs, is catalyzed by enzymes formerly
known as ThiI, but renamed here TtuI. Two different classes of TtuI proteins, which possess a …

Post-transcriptional modifications affect tRNA biology and are closely associated with
human diseases. However, progress on the functional analysis of tRNA modifications in …

The mechanisms by which the relatively conserved spliceosome manages the enormously
large number of splicing events that occur in humans (∼ 200 000 versus∼ 300 in yeast) are …

Chemical modifications expand the composition of RNA molecules from four standard
nucleosides to over 160 modified nucleosides, which greatly increase the complexity and …

To date, numerous modified nucleosides in tRNA as well as tRNA modification enzymes
have been identified not only in thermophiles but also in mesophiles. Because most …

Post-transcriptional and post-translational modifications are very important for the control
and optimal efficiency of messenger RNA (mRNA) translation. Among these, methylation is …