Review on machine learning-based bioprocess optimization, monitoring, and control systems
Abstract Machine Learning is quickly becoming an impending game changer for
transforming big data thrust from the bioprocessing industry into actionable output. However …
transforming big data thrust from the bioprocessing industry into actionable output. However …
Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …
Design of experiments (DoE) in pharmaceutical development
At the beginning of the twentieth century, Sir Ronald Fisher introduced the concept of
applying statistical analysis during the planning stages of research rather than at the end of …
applying statistical analysis during the planning stages of research rather than at the end of …
Clinical manufacturing of CAR T cells: foundation of a promising therapy
X Wang, I Rivière - Molecular Therapy-Oncolytics, 2016 - cell.com
The treatment of cancer patients with autologous T cells expressing a chimeric antigen
receptor (CAR) is one of the most promising adoptive cellular therapy approaches …
receptor (CAR) is one of the most promising adoptive cellular therapy approaches …
Understanding pharmaceutical quality by design
This review further clarifies the concept of pharmaceutical quality by design (QbD) and
describes its objectives. QbD elements include the following:(1) a quality target product …
describes its objectives. QbD elements include the following:(1) a quality target product …
An overview of experimental designs in HPLC method development and validation
Chemometric approaches have been increasingly viewed as precious complements to high
performance liquid chromatographic practices, since a large number of variables can be …
performance liquid chromatographic practices, since a large number of variables can be …
Spray drying formulation of amorphous solid dispersions
A Singh, G Van den Mooter - Advanced drug delivery reviews, 2016 - Elsevier
Spray drying is a well-established manufacturing technique which can be used to formulate
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …
amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water …
Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures
Introduction: Nanomedicine has emerged as a major field of academic research with direct
impact on human health. While a first generation of products has been successfully …
impact on human health. While a first generation of products has been successfully …
[HTML][HTML] The future of pharmaceutical manufacturing sciences
J Rantanen, J Khinast - Journal of pharmaceutical sciences, 2015 - Elsevier
The entire pharmaceutical sector is in an urgent need of both innovative technological
solutions and fundamental scientific work, enabling the production of highly engineered …
solutions and fundamental scientific work, enabling the production of highly engineered …
BCS class IV drugs: Highly notorious candidates for formulation development
BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …
exhibit many characteristics that are problematic for effective oral and per oral delivery …