Toll‐like receptors: general molecular and structural biology

P Behzadi, HA García-Perdomo… - Journal of Immunology …, 2021 - Wiley Online Library
Background/Aim. Toll‐like receptors (TLRs) are pivotal biomolecules in the immune system.
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …

Curcumin (a constituent of turmeric): New treatment option against COVID‐19

F Babaei, M Nassiri‐Asl… - Food science & …, 2020 - Wiley Online Library
In late December 2019, the outbreak of respiratory illness emerged in Wuhan, China, and
spreads worldwide. World Health Organization (WHO) named this disease severe acute …

[HTML][HTML] Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

W Liu, X Cui, Y Zhong, R Ma, B Liu, Y Xia - Pharmacological research, 2023 - Elsevier
Polyphenols, also known as phenolic compounds, are chemical substances containing
aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist …

Skin-targeted delivery of extracellular vesicle-encapsulated curcumin using dissolvable microneedle arrays

SS Yerneni, EP Yalcintas, JD Smith, S Averick… - Acta Biomaterialia, 2022 - Elsevier
Therapeutic benefits of curcumin for inflammatory diseases have been demonstrated.
However, curcumin's potential as a clinical therapeutic has been hindered due to its low …

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury

M Ashrafizadeh, Z Ahmadi… - Current Molecular …, 2020 - ingentaconnect.com
Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma
longa (turmeric). This medicinal compound has different biological activities, including …

Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Z Heidari, M Daei, M Boozari… - Phytotherapy …, 2022 - Wiley Online Library
This systematic review was designed to determine the clinical efficacy and safety of
curcumin supplementation for pediatric patients based on clinical trials in children. We …

Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection

K Burge, A Gunasekaran, J Eckert… - International journal of …, 2019 - mdpi.com
Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …

Toll‐like receptors in neuroinflammation, neurodegeneration, and alcohol‐induced brain damage

M Pascual, M Calvo‐Rodriguez, L Núñez… - IUBMB …, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) or pattern recognition receptors respond to pathogen‐associated
molecular patterns (PAMPs) or internal damage‐associated molecular patterns (DAMPs) …

Crocin molecular signaling pathways at a glance: A comprehensive review

M Boozari, H Hosseinzadeh - Phytotherapy Research, 2022 - Wiley Online Library
Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus.
Numerous in vitro and in vivo research projects have been published about the biological …

Viral proteins recognized by different TLRs

R Zhou, L Liu, Y Wang - Journal of Medical Virology, 2021 - Wiley Online Library
Virus invasion activates the host's innate immune response, inducing the production of
numerous cytokines and interferons to eliminate pathogens. Except for viral DNA/RNA, viral …