Human pluripotent stem cell-derived cardiomyocytes (hPS-CM) may offer a number of
advantages over previous cardiac models, however, questions of their immaturity complicate …

Bile acids (BA) are classically known as an important agent in lipid absorption and
cholesterol metabolism. Nowadays, their role in glucose regulation and energy homeostasis …

Objectives To test whether ursodeoxycholic acid reduces pruritus in women with intrahepatic
cholestasis of pregnancy, whether early term delivery does not increase the incidence of …

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are being developed for
tissue repair and as a model system for cardiac physiology and pathophysiology. However …

The harsh ischemic and cytokine-rich microenvironment in the infarcted myocardium,
infiltrated by the inflammatory and immune cells, offers a significant challenge to the …

Insulin‐like growth factor 1 (IGF1) and neuregulin‐1β (NRG1) play important roles during
cardiac development both individually and synergistically. In this study, we analyze how 3D …

Objective High bile acid serum concentrations have been implicated in cardiac disease,
particularly in arrhythmias. Most data originate from in vitro studies and animal models. We …

Background/Aims: Intrahepatic cholestasis of pregnancy (ICP) is complicated by
spontaneous preterm labor, fetal anoxia and unexplained fetal death. We aim to evaluate …

Human embryonic stem cells have emerged as the prototypical source from which
cardiomyocytes can be derived for use in drug discovery and cell therapy. However, such …

The current drug screening models are deficient, particularly in detecting cardiac side
effects. Human stem cell‐derived cardiomyocytes could aid both early cardiotoxicity …