Asiatic acid prevents cognitive deficits by inhibiting calpain activation and preserving synaptic and mitochondrial function in rats with kainic acid-induced seizure

CW Lu, TY Lin, TL Pan, PW Wang, KM Chiu, MY Lee… - Biomedicines, 2021 - mdpi.com
Cognitive impairment is not only associated with seizures but also reported as an adverse
effect of antiepileptic drugs. Thus, new molecules that can ameliorate seizures and maintain …

Pin1 promotes regulated necrosis induced by glutamate in rat retinal neurons via CAST/Calpain2 pathway

S Wang, L Liao, M Wang, H Zhou, Y Huang… - Frontiers in cellular …, 2018 - frontiersin.org
The purpose of the current study was to investigate whether peptidyl-prolyl cis/trans
isomerase NIMA-interacting 1 (Pin1) can interact with calpastatin (CAST) and regulate …

[HTML][HTML] Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels

J Zheng, S Min, B Hu, Q Liu… - … Journal of Molecular …, 2019 - spandidos-publications.com
The cardiopulmonary bypass (CPB) is an important risk factor for the development of
postoperative cognitive dysfunction (POCD). The pathological mechanism of the neuro …

Neurodegeneration: Effects of calorie restriction on the brain sirtuin protein levels

B Atalay, S Dogan, BO Gudu, E Yilmaz, A Ayden… - Behavioural Brain …, 2025 - Elsevier
Background Calorie restriction (CR) is suggested to activate protective mechanisms in
neurodegenerative diseases (NDDs). Despite existing literature highlighting the protective …

[HTML][HTML] A new human calpastatin skipped of the inhibitory region protects calpain-1 from inactivation and degradation

B Sparatore, M Pedrazzi, A Garuti, A Franchi… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Several human acute and chronic diseases involve calpain over-activation. However, the
mechanistic linkages between the etiology and the progression of cell damages are not yet …

Neurodegeneration in The Mice Brain: Effects of Calorie Restriction on Sirtuin Protein Levels.

B Atalay - 2020 - acikbilim.yok.gov.tr
Atalay B. Neurodegeneration in The Mice Brain: Effects of Calorie Restriction on Sirtuin
Protein Levels. Yeditepe University, Institute of Health Science, Doctoral Program in …