A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

The eukaryotic endomembrane system consists of multiple interconnected organelles. Rab
GTPases are organelle-specific markers that give identity to these membranes by recruiting …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late
endocytic compartments such as late endosomes and lysosomes. The mechanism of action …

The identification of genetic causes for Mendelian disorders has been based on the
collection of multi-incident families, linkage analysis, and sequencing of genes in candidate …

Endosomal protein sorting controls the localization of many physiologically important
proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the …

The endosomal network comprises an interconnected network of membranous
compartments whose primary function is to receive, dissociate, and sort cargo that originates …

Protein and lipid transport along the endolysosomal system of eukaryotic cells depends on
multiple fusion and fission events. Over the past few years, the molecular constituents of …

The PDZ-domain-containing sorting nexin 27 (SNX27) promotes recycling of internalized
transmembrane proteins from endosomes to the plasma membrane by linking PDZ …