RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

Ribosome biogenesis is a crucial process for growth and constitutes the major consumer of
cellular resources. This pathway is subjected to very stringent regulation to ensure correct …

The decay of mRNA plays a vital role in modulating mRNA abundance, which, in turn,
influences cellular and organismal processes. In plants and metazoans, three distinct …

Gene expression is regulated by the rates of synthesis and degradation of mRNAs, but how
these processes are coordinated is poorly understood. Here, we show that reduced …

Messenger RNA (mRNA) homeostasis represents an essential part of gene expression, in
which the generation of mRNA by RNA polymerase is counter-balanced by its degradation …

We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV)
contain regions in their 5'UTRs that stall and repress the enzymatic activity of the cellular 5' …

Aflatoxin B1 (AFB1) is a common toxin found in many foods. While AFB1 sensors have been
reported, few studies have shown amplified detection with tunable dynamic ranges. We …

Abstract The highly conserved 5'–3'exonuclease Xrn1 regulates gene expression in
eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating …

Gamma-herpesviruses encode a cytoplasmic mRNA-targeting endonuclease, SOX, that
cleaves most cellular mRNAs. Cleaved fragments are subsequently degraded by the cellular …

In the last decade, multiple studies demonstrated that cells maintain a balance of mRNA
production and degradation, but the mechanisms by which cells implement this balance …