Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications
MS Castaneto, DA Gorelick, NA Desrosiers… - Drug and alcohol …, 2014 - Elsevier
Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …
developed to probe the endogenous cannabinoid system or as potential therapeutics …
Potential mechanisms underlying the deleterious effects of synthetic cannabinoids found in spice/K2 products
BS Basavarajappa, S Subbanna - Brain Sciences, 2019 - mdpi.com
The chief psychoactive constituent of many bioactive phytocannabinoids (Δ9-
tetrahydrocannabinol, Δ9-THC) found in hemp, cannabis or marijuana plants are …
tetrahydrocannabinol, Δ9-THC) found in hemp, cannabis or marijuana plants are …
Δ9-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice
Abstract Δ 9-Tetrahydrocannabinol (THC) has been characterized as a partial agonist at
cannabinoid CB1 receptors in vitro; however, it often produces the same maximum effects in …
cannabinoid CB1 receptors in vitro; however, it often produces the same maximum effects in …
The synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse
Two novel adamantane derivatives, adamantan-1-yl (1-pentyl-1 H-indol-3-yl) methanone
(AB-001) and N-(adamtan-1-yl)-1-pentyl-1 H-indole-3-carboxamide (SDB-001), were …
(AB-001) and N-(adamtan-1-yl)-1-pentyl-1 H-indole-3-carboxamide (SDB-001), were …
Inhalation exposure to smoke from synthetic “marijuana” produces potent cannabimimetic effects in mice
JM Wiebelhaus, JL Poklis, A Poklis, RE Vann… - Drug and alcohol …, 2012 - Elsevier
BACKGROUND: Use of synthetic “marijuana” has increased in recent years, produced
adverse effects and prompted the temporary DEA ban of five specific cannabinoid analogs …
adverse effects and prompted the temporary DEA ban of five specific cannabinoid analogs …
Effects of cannabinoid agonists and antagonists in male rats discriminating the synthetic cannabinoid AM2201
The synthetic forms of delta-9-tetrahydrocannabinol (Δ 9-THC), dronabinol or nabilone, have
been approved to treat several indications. However, due to safety concerns their clinical …
been approved to treat several indications. However, due to safety concerns their clinical …
Altered sleep during spontaneous cannabinoid withdrawal in male mice
Cessation of cannabinoid use in humans often leads to a withdrawal state that includes
sleep disruption. Despite important health implications, little is known about how …
sleep disruption. Despite important health implications, little is known about how …
Cannabinoid discrimination and antagonism by CB1 neutral and inverse agonist antagonists
Cannabinoid receptor 1 (CB1) inverse agonists (eg, rimonabant) have been reported to
produce adverse effects including nausea, emesis, and anhedonia that limit their clinical …
produce adverse effects including nausea, emesis, and anhedonia that limit their clinical …
A critical assessment of the abuse, dependence and associated safety risks of naturally occurring and synthetic cannabinoids
DJ Heal, J Gosden, SL Smith - Frontiers in Psychiatry, 2024 - frontiersin.org
Various countries and US States have legalized cannabis, and the use of the psychoactive1
and non-psychoactive cannabinoids is steadily increasing. In this review, we have collated …
and non-psychoactive cannabinoids is steadily increasing. In this review, we have collated …
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats
TUC Järbe, BJ LeMay, A Halikhedkar, JA Wood… - …, 2014 - Springer
Rationale The “subjective high” from marijuana ingestion is likely due to Δ 9-
tetrahydrocannabinol (THC) activating the central cannabinoid receptor type 1 (CB 1 R) of …
tetrahydrocannabinol (THC) activating the central cannabinoid receptor type 1 (CB 1 R) of …