Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance
in type 1 diabetes (T1D). Tissue transglutaminase (tTG), involved in PTM of gluten antigens …

Measuring the chemical composition of individual cells in mammalian organs can provide
critical insights toward understanding the mechanisms leading to their normal and …

Cell-to-cell variability and functional heterogeneity are integral features of multicellular
organisms. Chemical classification of cells into cell type is important for understanding …

We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1
belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports …

The discovery of insulin in the early 1900s ushered in the era of research related to peptides
acting as hormones and neuromodulators, among other regulatory roles. These essential …

The secretory granule of the pancreatic β-cells is a zinc-rich environment copopulated with
the hormones amylin and insulin. The human amylin is shown to interact with zinc ions with …

Objectives To analyse the peptidomics of mouse enteroendocrine cells (EECs) and human
gastrointestinal (GI) tissue and identify novel gut derived peptides. Methods High resolution …

Peptide Hormone Acquisition through Smart Sampling Technique-Mass Spectrometry
(PHASST-MS) is a peptidomics platform that employs high resolution liquid chromatography …

Methods are described for determining the amount of insulin in a sample. More specifically,
mass spectrometric methods are described for detecting and quantifying insulin in a …

2018-12-20 Assigned to QUEST DIAGNOSTICS INVESTMENTS LLC reassignment QUEST
DIAGNOSTICS INVESTMENTS LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE …