The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases

E Possemato, L La Barbera, A Nobili, P Krashia… - Ageing research …, 2023 - Elsevier
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Cellular mechanisms of melatonin: insight from neurodegenerative diseases

D Chen, T Zhang, TH Lee - Biomolecules, 2020 - mdpi.com
Neurodegenerative diseases are the second most common cause of death and
characterized by progressive impairments in movement or mental functioning in the central …

Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer's disease in Tg2576 mice

L La Barbera, A Nobili, E Cauzzi, I Paoletti… - Molecular …, 2022 - Springer
Background Recent clinical and experimental studies have highlighted the involvement of
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …

[HTML][HTML] Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's Disease

L La Barbera, F Vedele, A Nobili, P Krashia… - Progress in …, 2021 - Elsevier
What happens precociously to the brain destined to develop Alzheimer's Disease (AD) still
remains to be elucidated and this is one reason why effective AD treatments are missing …

Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease

E Spoleti, L La Barbera, E Cauzzi, ML De Paolis… - Molecular …, 2024 - nature.com
Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental
Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre …

Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease

DM Kopustinskiene, J Bernatoniene - Pharmaceutics, 2021 - mdpi.com
Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

[HTML][HTML] Behavioral and psychological symptoms in dementia

N Cloak, Y Al Khalili - 2019 - europepmc.org
Behavioral and Psychological Symptoms in Dementia - Abstract - Europe PMC Sign in | Create
an account https://orcid.org Europe PMC Menu About Tools Developers Help Contact us …

Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer's disease: Current trends and future perspectives

L La Barbera, E Mauri, M D'Amelio… - Frontiers in neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common form of dementia, is a progressive and
multifactorial neurodegenerative disorder whose primary causes are mostly unknown. Due …

Unifying hypothesis of dopamine neuron loss in neurodegenerative diseases: focusing on Alzheimer's disease

P Krashia, A Nobili, M D'Amelio - Frontiers in molecular neuroscience, 2019 - frontiersin.org
The term “dementia” describes a syndrome caused by several illnesses in which there is
progressive decline in multiple areas of brain function. The main form of dementia is …

[HTML][HTML] In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease

L Serra, M D'Amelio, C Di Domenico, O Dipasquale… - Neurobiology of …, 2018 - Elsevier
We assessed here functional connectivity changes in the locus coeruleus (LC) and ventral
tegmental area (VTA) of patients with Alzheimer's disease (AD). We recruited 169 patients …