Artificial intelligence aids in development of nanomedicines for cancer management

P Tan, X Chen, H Zhang, Q Wei, K Luo - Seminars in cancer biology, 2023 - Elsevier
Over the last decade, the nanomedicine has experienced unprecedented development in
diagnosis and management of diseases. A number of nanomedicines have been approved …

New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Engineering radiosensitizer‐based metal‐phenolic networks potentiate STING pathway activation for advanced radiotherapy

J Yan, G Wang, L Xie, H Tian, J Li, B Li… - Advanced …, 2022 - Wiley Online Library
Radiotherapy, a mainstay of first‐line cancer treatment, suffers from its high‐dose radiation‐
induced systemic toxicity and radioresistance caused by the immunosuppressive tumor …

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Nanomedicine for brain cancer

S Quader, K Kataoka, H Cabral - Advanced Drug Delivery Reviews, 2022 - Elsevier
CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

Surface engineering of lanthanide nanoparticles for oncotherapy

Z Luo, Z Yi, X Liu - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Surface-modified lanthanide nanoparticles have been widely developed as an
emerging class of therapeutics for cancer treatment because they exhibit several unique …

Transforming nuclear medicine with nanoradiopharmaceuticals

I Roy, S Krishnan, AV Kabashin, IN Zavestovskaya… - ACS …, 2022 - ACS Publications
Nuclear medicine is expected to make major advances in cancer diagnosis and therapy;
tumor-targeted radiopharmaceuticals preferentially eradicate tumors while causing minimal …

Radiation‐induced immunogenic cell death for cancer radioimmunotherapy

T Liu, P Pei, W Shen, L Hu, K Yang - Small Methods, 2023 - Wiley Online Library
In cancer treatment, traditional radiotherapy (RT) is routinely conducted in local tumors and
limited by radioresistance, while recently emerged immunotherapy is confronted with low …

Anticancer nanotherapeutics in clinical trials: The work behind clinical translation of nanomedicine

A Parodi, EP Kolesova, MV Voronina… - International Journal of …, 2022 - mdpi.com
The ultimate goal of nanomedicine has always been the generation of translational
technologies that can ameliorate current therapies. Cancer disease represented the primary …

Prospects of nanoparticle-based radioenhancement for radiotherapy

LRH Gerken, ME Gerdes, M Pruschy… - Materials horizons, 2023 - pubs.rsc.org
Radiotherapy is a key pillar of solid cancer treatment. Despite high level of conformal dose
deposition, radiotherapy is limited due to co-irradiation of organs-at risk and subsequent …