Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Summary Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids,
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …

APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …

Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …

Astrocytes metabolically interact with neighboring neurons by providing multiple substances
to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic …

In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-
density lipoproteins and lower capacity of high-density lipoproteins to remove cellular …

Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …

Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its
biosynthesis is severely reduced in mouse models of Huntington's disease. One possible …

Alzheimer's disease (AD) is the most common cause of dementia. A genome‐wide
association study has shown that several AD risk genes are involved in lipid metabolism …