Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
Involvement of lipids in Alzheimer's disease pathology and potential therapies
H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …
function as well as the most common pathological conditions of the brain. Demographic …
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
AD Marais - Pathology, 2019 - Elsevier
Summary Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids,
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …
The role of APOE4 in disrupting the homeostatic functions of astrocytes and microglia in aging and Alzheimer's disease
CG Fernandez, ME Hamby, ML McReynolds… - Frontiers in aging …, 2019 - frontiersin.org
APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …
Brain cell type-specific cholesterol metabolism and implications for learning and memory
Cholesterol homeostasis is vital for brain function. Brain cholesterol is locally synthesized,
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
with varying synthesis capacities across different cell types. Moreover, brain cholesterol …
[HTML][HTML] Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory
X Li, J Zhang, D Li, C He, K He, T Xue, L Wan, C Zhang… - Neuron, 2021 - cell.com
Astrocytes metabolically interact with neighboring neurons by providing multiple substances
to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic …
to neurons. How astrocytes regulate neural functions via altering the neuronal metabolic …
[HTML][HTML] Cholesterol metabolism in aging simultaneously altered in liver and nervous system
VS Nunes, G da Silva Ferreira, ECR Quintão - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-
density lipoproteins and lower capacity of high-density lipoproteins to remove cellular …
density lipoproteins and lower capacity of high-density lipoproteins to remove cellular …
The translational potential of cholesterol-based therapies for neurological disease
M Valenza, G Birolini, E Cattaneo - Nature Reviews Neurology, 2023 - nature.com
Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes
G Birolini, G Verlengia, F Talpo, C Maniezzi, L Zentilin… - Brain, 2021 - academic.oup.com
Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its
biosynthesis is severely reduced in mouse models of Huntington's disease. One possible …
biosynthesis is severely reduced in mouse models of Huntington's disease. One possible …
Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities
N Kawade, K Yamanaka - FEBS Open bio, 2024 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia. A genome‐wide
association study has shown that several AD risk genes are involved in lipid metabolism …
association study has shown that several AD risk genes are involved in lipid metabolism …