RNA plays many different roles in biological systems. characteristic marker mutations from
the parental RNAs. One of RNAs most intriguing features is the ability to Following the initial …

Publisher Summary It is clear from the experimental data that there are some similarities in
RNA replication for all eukaryotic positive-stranded RNA viruses—that is, the mechanism of …

Hepatitis C virus (HCV) is the major etiological agent of non‐A, non‐B post‐transfusion
hepatitis. Its genome, a (+)‐stranded RNA molecule of approximately 9.4 kb, encodes a …

A small protein, VPg, is covalently linked to the 5′ end of the plus-stranded poliovirus
genomic RNA,,. Poliovirus messenger RNA, identical in nucleotide sequence to genomic …

Poliovirus RNA replication occurs on the surface of membranous vesicles that proliferate
throughout the cytoplasm of the infected cell. Since at least some of these vesicles are …

Human immunodeficiency virus type 1 (HIV‐1) variants with resistance mutations in the
reverse transcriptase (RT) gene appear during drug therapy with the nucleoside analogue …

On the basis of sequence alignments and secondary structure comparisons of the first 100
nucleotides of enterovirus and rhinovirus RNAs, chimeric constructs in which this region of …

Members of the Picornaviridae are positive-strand RNA viruses that cause a variety of
human diseases such as poliomyelitis, the common cold, myocarditis, and hepatitis …

Poliovirus protein 3A, only 87 amino acids in length, is a potent inhibitor of protein secretion
in mammalian cells, blocking anterograde protein traffic from the endoplasmic reticulum …

The 7.5-kb plus-stranded genomic RNA of rabbit hemorrhagic disease virus contains two
open reading frames of 7 kb (ORF1) and 351 nucleotides (ORF2) that cover nearly 99% of …