Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

Aging and metabolism are inextricably linked, and many age-related changes in body
composition, including increased central adiposity and sarcopenia, have underpinnings in …

In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Prostaglandins are lipid mediators involved in physiological processes, such as constriction
or dilation of blood vessels, but also pathophysiological processes, which include …

Sarcopenia, a geriatric syndrome that is characterized by a progressive and generalized
skeletal muscle disorder, can be associated with many comorbidities, including obesity …

Skeletal muscle is the most abundant type of tissue in human body, being involved in
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …

During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases,
diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs …

Background Aging is generally associated with numerous metabolic and physical changes
that augment susceptibility to several chronic conditions, disability, and diminished quality of …