The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Highlights•Elderly people commonly show signs of low level systemic inflammation.•Causes
include presence of senescent cells, chronic infections and obesity.•Systemic inflammation …

To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …

Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and
sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been …

Introduction Inflammation is believed to be a contributing factor to many chronic diseases.
The influence of vitamin D deficiency on inflammation is being explored but studies have not …

Background Elderly patients are more likely to suffer from postoperative cognitive
dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the …

Background. Multimorbidity increases with aging, but risk factors beyond age are unknown.
Objective. To investigate the association of inflammatory and anabolic hormonal biomarkers …

Physical activity is key for successful ageing, but questions remain regarding the optimal
physical activity pattern. We examined the cross-sectional association between physical …

Oxidative stress, considered as a major culprit in brain aging, triggers cognitive and memory
impairment. Lycopene (LYC), a carotenoid pigment, possesses potent antioxidative, anti …

Abstract Purpose of the Study Few studies have recommended the essential domains of
healthy aging and their relevant measurement to assess healthy aging comprehensively …