The management of retinoblastoma, the most common intraocular malignancy in children,
has changed drastically over the last decade. Landmark developments in local drug …

Since the discovery of the retinoblastoma susceptibility gene (RB1) decades ago, RB1 has
been regarded as a prototype tumor suppressor gene providing a paradigm for tumor …

Retinoblastoma (RB) is a cancer that forms in the developing retina of babies and toddlers.
The goal of therapy is to cure the tumor, save the eye and maximize vision. However, it is …

Background Recurrence of retinoblastoma (RB) following chemoreduction is common and is
often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors …

The emergence of retinal progenitor cells and differentiation to various retinal cell types
represent fundamental processes during retinal development. Herein, we provide a …

Retinoblastoma, the most prevalent primary intraocular tumor in children, leads to vision
impairment, disability and even death. In addition to RB1 inactivation, MYCN activation has …

Most retinoblastomas develop from maturing cone precursors in response to biallelic RB1
loss and are dependent on cone maturation-related signaling. Additionally,∼ 2% lack RB1 …

This review presents current knowledge on the molecular biology of retinoblastoma (RB).
Retinoblastoma is an intraocular tumor with hereditary and sporadic forms. 8,000 new cases …

Retinoblastoma is the most common paediatric neoplasm of the retina, and one of the
earliest model of cancer genetics since the identification of the master tumour suppressor …

Simple Summary Effective management of retinoblastoma (RB), a common childhood eye
cancer, requires accurate diagnosis and monitoring during therapy. In this study, the liquid …