Compelling evidence supports a tight link between oxidative stress and protein aggregation
processes, which are noticeably involved in the development of proteinopathies, such as …

Cysteine thiols are among the most reactive functional groups in proteins, and their pairing
in disulfide linkages is a common post-translational modification in proteins entering the …

Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

UV light and other factors damage crystallin proteins in the eye lens, resulting in cataracts
that scatter light and affect vision. Little information exists about protein structures within …

Conspectus Crystallins are transparent, refractive proteins that contribute to the focusing
power of the vertebrate eye lens. These proteins are extremely soluble and resist …

Alzheimer's disease (AD) is a progressive neurodegenerative disease accompanied by
irreversible cognitive impairment. A deleterious feedback loop between oxidative stress and …

Increased light scattering in the eye lens due to aggregation of the long-lived lens proteins,
crystallins, is the cause of cataract disease. Several mutations in the gene encoding human …

It is well established that both an increase in reactive oxygen species (ROS: ie O2•−, H2O2
and OH•), as well as protein aggregation, accompany ageing and proteinopathies such as …

The nuclear region of the lens is metabolically quiescent, but it is far from inert chemically.
Without cellular renewal and with decades of environmental exposures, the lens proteome …