Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

Background This study aimed to investigate the association between the systemic immune-
inflammation index (SII) and bone mineral density (BMD) and to determine the association …

Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will
provide insights into skeletal development and genetic skeletal disorders and will generate …

Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Sulfation is a widespread modification of biomolecules that has been incompletely explored
to date. Through cross-phenotype meta-analysis of bone mineral density in up to 426,824 …

Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial
resolution in live animals. However, the endosteal bone compartment and underlying bone …

Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing
osteocytes. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly …

Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …