Macrophages: From simple phagocyte to an integrative regulatory cell for inflammation and tissue regeneration—A review of the literature
A Mamilos, L Winter, VH Schmitt, F Barsch… - Cells, 2023 - mdpi.com
The understanding of macrophages and their pathophysiological role has dramatically
changed within the last decades. Macrophages represent a very interesting cell type with …
changed within the last decades. Macrophages represent a very interesting cell type with …
Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic …
J Han, L Dong, M Wu, F Ma - Frontiers in Immunology, 2023 - frontiersin.org
Immunotherapy has brought a paradigm shift in the treatment of tumors in recent decades.
However, a significant proportion of patients remain unresponsive, largely due to the …
However, a significant proportion of patients remain unresponsive, largely due to the …
Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis
Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages
which respond to an initial inflammatory insult common in all forms of fibrosis. The recently …
which respond to an initial inflammatory insult common in all forms of fibrosis. The recently …
[HTML][HTML] Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss
JA Larouche, EC Wallace, BD Spence, E Buras… - JCI insight, 2023 - ncbi.nlm.nih.gov
Volumetric muscle loss (VML) is an acute trauma that results in persistent inflammation,
supplantation of muscle tissue with fibrotic scarring, and decreased muscle function. The cell …
supplantation of muscle tissue with fibrotic scarring, and decreased muscle function. The cell …
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis
Group 2 innate lymphoid cells (ILC2s) cooperate with adaptive Th2 cells as key organizers
of tissue type 2 immune responses, while a spectrum of innate and adaptive lymphocytes …
of tissue type 2 immune responses, while a spectrum of innate and adaptive lymphocytes …
Negative Modulation of B Cell Activation by Melanocortin 1 Receptor Signaling Protects against Membranous Nephropathy
B Chen, X Guan, WT Gunning, Y Ge… - Journal of the …, 2023 - journals.lww.com
Background Emerging evidence suggests that the pituitary neuropeptide melanocortins—
specifically, adrenocorticotropic hormone—offer a novel nonsteroidogenic therapeutic …
specifically, adrenocorticotropic hormone—offer a novel nonsteroidogenic therapeutic …