Applications of discrete synthetic macromolecules in life and materials science: recent and future trends

R Aksakal, C Mertens, M Soete, N Badi… - Advanced …, 2021 - Wiley Online Library
In the last decade, the field of sequence‐defined polymers and related ultraprecise,
monodisperse synthetic macromolecules has grown exponentially. In the early stage, mainly …

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

WS Horne, TN Grossmann - Nature chemistry, 2020 - nature.com
Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …

Helical oligourea foldamers as powerful hydrogen bonding catalysts for enantioselective C–C bond-forming reactions

D Bécart, V Diemer, A Salaun, M Oiarbide… - Journal of the …, 2017 - ACS Publications
Substantial progress has been made toward the development of metal-free catalysts of
enantioselective transformations, yet the discovery of organic catalysts effective at low …

The diverse world of foldamers: endless possibilities of self-assembly

S Rinaldi - Molecules, 2020 - mdpi.com
Different classes of foldamers, which are synthetic oligomers that adopt well-defined
conformations in solution, have been the subject of extensive studies devoted to the …

Homochiral versus Heterochiral Dimeric Helical Foldamer Bundles: Chlorinated‐Solvent‐Dependent Self‐Sorting

FS Menke, B Wicher, V Maurizot… - Angewandte Chemie …, 2023 - Wiley Online Library
Aromatic oligoamide sequences programmed to fold into stable helical conformations were
designed to display a linear array of hydrogen‐bond donors and acceptors at their surface …

Crystal Structure and NMR of an α, δ‐Peptide Foldamer Helix Shows Side‐Chains are Well Placed for Bifunctional Catalysis: Application as a Minimalist Aldolase …

Q Lin, H Lan, C Ma, RT Stendall… - Angewandte Chemie …, 2023 - Wiley Online Library
We report the first NMR and X‐ray diffraction (XRD) structures of an unusual 13/11‐helix
(alternating i, i+ 1 {NH− O= C} and i, i+ 3 {C= O− H− N} H‐bonds) formed by a heteromeric 1 …

Parallel Homochiral and Anti‐Parallel Heterochiral Hydrogen‐Bonding Interfaces in Multi‐Helical Abiotic Foldamers

D Mazzier, S De, B Wicher… - Angewandte Chemie …, 2020 - Wiley Online Library
A hydrogen‐bonding interface between helical aromatic oligoamide foldamers has been
designed to promote the folding of a helix‐turn‐helix motif with a head‐to‐tail arrangement …

Adaptive binding of alkyl glycosides by nonpeptidic helix bundles in water: toward artificial glycolipid binding proteins

SH Yoo, J Buratto, A Roy, E Morvan… - Journal of the …, 2022 - ACS Publications
Amphipathic water-soluble helices formed from synthetic peptides or foldamers are
promising building blocks for the creation of self-assembled architectures with non-natural …

Abiotic foldamer quaternary structures

S Wang, L Allmendinger, I Huc - … Chemie International Edition, 2024 - Wiley Online Library
Abiotic aromatic foldamer sequences have been previously shown to fold in helix‐turn‐helix
motifs in organic solvents. Using simple computational tools, a new helix‐turn‐helix motif …

Site-selective post-modification of short α/γ hybrid foldamers: a powerful approach for molecular diversification towards biomedical applications

SKH Shah, U Modi, K Patel, A James, N Sreerag… - Biomaterials …, 2023 - pubs.rsc.org
The extensive research work in the exhilarating area of foldamers (artificial oligomers
possessing well-defined conformation in solution) has shown them to be promising …