Tumour-intrinsic resistance to immune checkpoint blockade

A Kalbasi, A Ribas - Nature Reviews Immunology, 2020 - nature.com
Abstract 'Immune checkpoint blockade'for cancer describes the use of therapeutic antibodies
that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour …

Immunotherapy: a challenge of breast cancer treatment

M García-Aranda, M Redondo - Cancers, 2019 - mdpi.com
Breast cancer is the most commonly diagnosed cancer in women and is a leading cause of
cancer death in women worldwide. Despite the significant benefit of the use of conventional …

Risk of developing checkpoint immune pneumonitis and its effect on overall survival in non-small cell lung cancer patients previously treated with radiotherapy

F Barrón, R Sánchez, M Arroyo-Hernández… - Frontiers in …, 2020 - frontiersin.org
Introduction Immune checkpoint inhibitor-related pneumonitis (ICIP) is a potentially life
threatening immune-related adverse event (irAE), especially in non-small cell lung cancer …

[HTML][HTML] A phase 1b study to evaluate the safety and efficacy of durvalumab in combination with tremelimumab or danvatirsen in patients with relapsed or refractory …

V Ribrag, ST Lee, D Rizzieri, MJS Dyer, L Fayad… - … Myeloma and Leukemia, 2021 - Elsevier
Background Despite recent advances, outcomes in patients with relapsed/refractory diffuse
large B-cell lymphoma (DLBCL) remain poor. Immune checkpoint inhibitors have shown …

Neutrophils in cancer, a love–hate affair

D Cerezo‐Wallis, I Ballesteros - The Febs Journal, 2022 - Wiley Online Library
Neutrophils dominate the immunological landscape of multiple types of solid tumours in
mice and humans and exert different pro‐or antitumoral activity. This functional …

Nivolumab monotherapy or combination therapy with ipilimumab for lung cancer: a systemic review and meta-analysis

H Jiang, A Xu, W Xia, X Xia, P Li, B Zhang, K Zhu… - Cancer cell …, 2021 - Springer
Background The high incidence and mortality of lung cancer have seriously affected human
life and health. Nivolumab is a monoclonal antibody that can inhibit programmed death 1 …

Talimogene laherparepvec (T‐VEC) in advanced melanoma: complete response in a heart and kidney transplant patient. A case report

J Ressler, R Silmbrod, A Stepan… - British Journal of …, 2019 - academic.oup.com
Talimogene laherparepvec (T‐VEC) is a intralesional oncolytic virotherapy, licensed in the
European Union for locoregional advanced melanoma of American Joint Committee on …

The efficacy and safety of combined ipilimumab and nivolumab versus ipilimumab in patients with Stage III/IV unresectable melanoma: A systematic review and meta …

Y Zhu, H Cheng, M Zhong, Y Hu, Q Li… - Journal of Cancer …, 2021 - journals.lww.com
Background: In this meta-analysis, we compared the clinical efficacy and safety of
ipilimumab/nivolumab combination therapy with those of ipilimumab monotherapy for stage …

Association of survival and immune-related adverse events with anti-PD-1/PD-L1 and anti-CTLA-4 inhibitors, alone or their combination for the treatment of cancer: a …

L Zhang, L Sun, Y Zhou, J Yu, Y Lin, HS Wasan… - Frontiers in …, 2021 - frontiersin.org
Background Cancer, with sustained high mortality, is a worldwide threat to public health.
Despite the survival benefit over conventional therapies shown in immune checkpoint …

Rational combination of parvovirus H1 with CTLA-4 and PD-1 checkpoint inhibitors dampens the tumor induced immune silencing

K Goepfert, C Dinsart, J Rommelaere, F Foerster… - Frontiers in …, 2019 - frontiersin.org
The recent therapeutic success of immune checkpoint inhibitors in the treatment of
advanced melanoma highlights the potential of cancer immunotherapy. Oncolytic virus …