Mechanism and inhibition of matrix metalloproteinases
Matrix metalloproteinases hydrolyze proteins and glycoproteins forming the extracellular
matrix, cytokines and growth factors released in the extracellular space, and membrane …
matrix, cytokines and growth factors released in the extracellular space, and membrane …
NMR of macromolecular assemblies and machines at 1 GHz and beyond: new transformative opportunities for molecular structural biology
As a result of profound gains in sensitivity and resolution afforded by ultrahigh magnetic
fields, transformative applications in the fields of structural biology and materials science are …
fields, transformative applications in the fields of structural biology and materials science are …
Epitope mapping and binding assessment by solid-state NMR provide a way for the development of biologics under the quality by design paradigm
D Rizzo, L Cerofolini, S Giuntini, L Iozzino… - Journal of the …, 2022 - ACS Publications
Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins
designed to bind pharmacological targets are covalently linked or expressed as fusion …
designed to bind pharmacological targets are covalently linked or expressed as fusion …
Insights into the interaction between immobilized biocatalysts and metal–organic frameworks: a case study of PCN-333
W Yang, W Liang, LA O'Dell, HD Toop, N Maddigan… - JACS Au, 2021 - ACS Publications
The immobilization of enzymes in metal–organic frameworks (MOFs) with preserved
biofunctionality paves a promising way to solve problems regarding the stability and …
biofunctionality paves a promising way to solve problems regarding the stability and …
Characterization of PEGylated Asparaginase: new opportunities from NMR analysis of large PEGylated therapeutics
L Cerofolini, S Giuntini, A Carlon… - … A European Journal, 2019 - Wiley Online Library
Resonance assignment and structural characterization of pharmacologically relevant
proteins promise to improve understanding and safety of these proteins by rational design …
proteins promise to improve understanding and safety of these proteins by rational design …
Investigating the role of phosphorylation in the binding of silaffin peptide R5 to silica with molecular dynamics simulations
Biomimetic silica formation, a process that is largely driven by proteins, has garnered
considerable interest in recent years due to its role in the development of new …
considerable interest in recent years due to its role in the development of new …
Multivariate curve resolution for 2D solid-state NMR spectra
We present a processing method, based on the multivariate curve resolution approach
(MCR), to denoise 2D solid-state NMR spectra, yielding a substantial S/N ratio increase …
(MCR), to denoise 2D solid-state NMR spectra, yielding a substantial S/N ratio increase …
Solid-state NMR methods for the characterization of bioconjugations and protein-material interactions
Protein solid-state NMR has evolved dramatically over the last two decades, with the
development of new hardware and sample preparation methodologies. This technique is …
development of new hardware and sample preparation methodologies. This technique is …
Biosilica and bioinspired silica studied by solid-state NMR
Bio-inspired materials are emerging as a powerful tool to tackle significant technological
problems, from biomedical engineering to green chemistry. In this review we demonstrate …
problems, from biomedical engineering to green chemistry. In this review we demonstrate …
Atomic structural details of a protein grafted onto gold nanoparticles
The development of a methodology for the structural characterization at atomic detail of
proteins conjugated to nanoparticles would be a breakthrough in nanotechnology. Solution …
proteins conjugated to nanoparticles would be a breakthrough in nanotechnology. Solution …