[HTML][HTML] Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
[PDF][PDF] Neurodegeneration cell per cell
S Balusu, R Praschberger, E Lauwers, B De Strooper… - Neuron, 2023 - cell.com
The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …
terminal damage of specific brain regions. This is misleading as it tells little about the initial …
[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes
J Schwartzentruber, S Cooper, JZ Liu… - Nature …, 2021 - nature.com
Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
AP Wingo, Y Liu, ES Gerasimov, J Gockley… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Brain proteome-wide association study implicates novel proteins in depression pathogenesis
TS Wingo, Y Liu, ES Gerasimov, J Gockley… - Nature …, 2021 - nature.com
Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …
individuals. To identify new treatment targets, we integrated depression genome-wide …
[HTML][HTML] Sex differences in brain protein expression and disease
Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …
mechanisms. Here, we investigated the influence of biological sex on protein expression …
Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain
Structural variants (SVs), which are genomic rearrangements of more than 50 base pairs,
are an important source of genetic diversity and have been linked to many diseases …
are an important source of genetic diversity and have been linked to many diseases …
[HTML][HTML] Prioritization of potential causative genes for schizophrenia in placenta
Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …
complications in affecting risk for the disorder and sex-biased neurodevelopmental …