Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies
M Moradi, A Mousavi, Z Emamgholipour… - European Journal of …, 2023 - Elsevier
Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …
the migration, growth, and differentiation of endothelial cells in normal physiological …
Therapeutic progression of quinazolines as targeted chemotherapeutic agents
R Bansal, A Malhotra - European Journal of Medicinal Chemistry, 2021 - Elsevier
Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …
Medicinal chemistry of quinazolines as anticancer agents targeting tyrosine kinases
MF Zayed - Scientia Pharmaceutica, 2023 - mdpi.com
Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …
Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer …
MF Ahmed, EY Santali, R El-Haggar - Journal of enzyme inhibition …, 2021 - Taylor & Francis
New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …
Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry
D Das, J Hong - European Journal of Medicinal Chemistry, 2019 - Elsevier
The 4-aminoquinazoline core is an interesting pharmacophore and its applications in
medicinal chemistry are wide spread. The core has been used for making many kinase …
medicinal chemistry are wide spread. The core has been used for making many kinase …
Discovery of potent thieno [2, 3-d] pyrimidine VEGFR-2 inhibitors: Design, synthesis and enzyme inhibitory evaluation supported by molecular dynamics simulations
EZ Elrazaz, RAT Serya, NSM Ismail, A Albohy… - Bioorganic …, 2021 - Elsevier
Vascular endothelial growth factor receptor (VEGFR) is one of the well-known targets that
control angiogenesis and cancer progression. In this study, we are reporting the design …
control angiogenesis and cancer progression. In this study, we are reporting the design …
Targeting the interplay between MMP-2, CA II and VEGFR-2 via new sulfonamide-tethered isomeric triazole hybrids; Microwave-assisted synthesis, computational …
Recently, the interest in targeting metalloenzymes is obviously growing for halting various
tumor progression events and surmounting the resistance due to routine chemotherapy …
tumor progression events and surmounting the resistance due to routine chemotherapy …
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors
Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2)
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
Dual VEGFR-2/PIM-1 kinase inhibition towards surmounting the resistance to antiangiogenic agents via hybrid pyridine and thienopyridine-based scaffolds: Design …
OH Rizk, M Teleb, MM Abu-Serie, OG Shaaban - Bioorganic Chemistry, 2019 - Elsevier
Angiogenesis is a hallmark in cancer. Most antiangiogenic agents block the action of
vascular endothelial growth factor (VEGF). In clinic, patients develop hypoxia-mediated …
vascular endothelial growth factor (VEGF). In clinic, patients develop hypoxia-mediated …
3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: design, synthesis and …
Abstract A series of novel 6, 7-dihydro-5H-cyclopenta [d] pyrimidine derivatives was
successfully designed, synthesized and evaluated as a new chemical scaffold with vascular …
successfully designed, synthesized and evaluated as a new chemical scaffold with vascular …