[HTML][HTML] Insulin resistance: from mechanisms to therapeutic strategies
SH Lee, SY Park, CS Choi - Diabetes & metabolism journal, 2022 - ncbi.nlm.nih.gov
Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …
[PDF][PDF] Mechanisms and disease consequences of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …
to the rapidly increased prevalence of overweight and obesity. To this point …
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
[HTML][HTML] Role of insulin resistance in MAFLD
Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …
[HTML][HTML] Mechanisms of insulin action and insulin resistance
MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
[HTML][HTML] Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy
R Dhanya - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Background Quercetin, a bioflavonoid abundant in grapefruit, onion, berries, etc., has vast
therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin …
therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin …
Brain insulin signalling in metabolic homeostasis and disease
T Scherer, K Sakamoto, C Buettner - Nature Reviews Endocrinology, 2021 - nature.com
Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …
Regulation of hepatic glucose metabolism in health and disease
MC Petersen, DF Vatner, GI Shulman - Nature reviews endocrinology, 2017 - nature.com
The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …
during fasting and stores glucose postprandially. However, these hepatic processes are …
[PDF][PDF] Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases
VT Samuel, GI Shulman - Cell metabolism, 2018 - cell.com
NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …