This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …

The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …

EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling
and a therapeutic target in cardiac diseases. The recent discovery that cAMP is …

Rationale: Although the second messenger cyclic AMP (cAMP) is physiologically beneficial
in the heart, it largely contributes to cardiac disease progression when dysregulated. Current …

Abstract cAMP is a universal second messenger. Its signalling is mediated by protein kinase
A, Epac and certain types of ion channels in mammalians. cAMP signalling is involved in …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation
of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling …

The pleiotropic second-messenger cAMP plays a crucial role in mediating the effects of
various hormones on metabolism. The major intracellular functions of cAMP are transduced …