To assess the critical role of Wnt signals in intestinal crypts, we generated transgenic mice
ectopically expressing Dickkopf1 (Dkk1), a secreted Wnt inhibitor. We find that epithelial …

RNA-fluorescence in situ hybridization (FISH) is a powerful tool to visualize target
messenger RNA transcripts in cultured cells, tissue sections or whole-mount preparations …

While the heart regenerates poorly in mammals, efficient heart regeneration occurs in
zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes …

A significant bottleneck in cardiovascular regenerative medicine is the identification of a
viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart …

The self-renewing epithelium of the small intestine is ordered into stem/progenitor crypt
compartments and differentiated villus compartments. Recent evidence indicates that the …

Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss
of proliferating crypt progenitors due to their conversion into postmitotic secretory cells. We …

The endothelium expresses a large repertoire of genes under apparent transcriptional
control of biomechanical forces, many of which are neither cell-type nor flow specific. We set …

Wnt signalling, which is transduced through β-catenin/TCF4, maintains the undifferentiated
state of intestinal crypt progenitor cells,. Mutational activation of the pathway initiates the …

In contrast to mammals, zebrafish regenerate heart injuries via proliferation of
cardiomyocytes located near the wound border. To identify regulators of cardiomyocyte …

The sinoatrial node initiates the heartbeat and controls the rate and rhythm of contraction,
thus serving as the pacemaker of the heart. Despite the crucial role of the sinoatrial node in …