The desulfurization reaction introduced by Yan and Dawson as a postnative chemical
ligation step greatly expanded the scope of ligation chemistry beyond Xaa-Cys (Xaa is any …

An efficient synthetic route to a suitably protected β-selenol-phenylalanine derivative from
commercially available Garner's aldehyde is described. The incorporation of this building …

Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from
Human Parathyroid Hormone and Analogues | Journal of the American Chemical Society ACS …

One of the condensation methods for the preparation of long-chain peptides, the so-called
thioester method requires protecting groups for amino and thiol groups for regioselective …

We describe herein the assembly of hEPO (79–166), a key glycopeptide segment en route
to erythropoietin, in minimally protected form. Key to the success of this synthetic endeavor …