Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
[HTML][HTML] Role of glioblastoma stem cells in cancer therapeutic resistance: A perspective on antineoplastic agents from natural sources and chemical derivatives
ALV Alves, INF Gomes, AC Carloni, MN Rosa… - Stem Cell Research & …, 2021 - Springer
Glioblastoma (GBM) is the highest-grade form of glioma, as well as one of the most
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
aggressive types of cancer, exhibiting rapid cellular growth and highly invasive behavior …
[HTML][HTML] CAR T cell-based immunotherapy for the treatment of glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in adults. Current treatment options typically consist of surgery followed by …
tumor in adults. Current treatment options typically consist of surgery followed by …
Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in glioblastoma
M Castellan, A Guarnieri, A Fujimura, F Zanconato… - Nature cancer, 2021 - nature.com
Glioblastoma (GBM) is a devastating human malignancy. GBM stem-like cells (GSCs) drive
tumor initiation and progression. Yet the molecular determinants defining GSCs in their …
tumor initiation and progression. Yet the molecular determinants defining GSCs in their …
Macrophages in tumor microenvironments and the progression of tumors
NB Hao, MH Lü, YH Fan, YL Cao… - Journal of …, 2012 - Wiley Online Library
Macrophages are widely distributed innate immune cells that play indispensable roles in the
innate and adaptive immune response to pathogens and in‐tissue homeostasis …
innate and adaptive immune response to pathogens and in‐tissue homeostasis …
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Glioblastoma is a highly angiogenetic malignancy, the neoformed vessels of which are
thought to arise by sprouting of pre-existing brain capillaries. The recent demonstration that …
thought to arise by sprouting of pre-existing brain capillaries. The recent demonstration that …
[HTML][HTML] Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis
M Buccarelli, M Marconi, S Pacioni, I De Pascalis… - Cell death & …, 2018 - nature.com
The role of autophagy in cancer onset and progression appears still controversial. On one
hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on …
hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on …
[HTML][HTML] Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
Inactivation of cancer stem cells (CSCs) is of utmost importance for tumor cure after
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …
radiotherapy. An increasing body of evidence complies with a higher radioresistance of …
[HTML][HTML] Glioblastoma: microenvironment and niche concept
D Schiffer, L Annovazzi, C Casalone, C Corona… - Cancers, 2018 - mdpi.com
The niche concept was originally developed to describe the location of normal neural stem
cells (NSCs) in the subependymal layer of the sub-ventricular zone. In this paper, its …
cells (NSCs) in the subependymal layer of the sub-ventricular zone. In this paper, its …
Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors
Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …