Nitric oxide/nitric oxide synthase system in the pathogenesis of neurodegenerative disorders—an overview

OM Iova, GE Marin, I Lazar, I Stanescu, G Dogaru… - Antioxidants, 2023 - mdpi.com
Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule
implicated in many central and benefic molecular pathways and has a well-established role …

An overview of NO signaling pathways in aging

AM Pourbagher-Shahri, T Farkhondeh, M Talebi… - Molecules, 2021 - mdpi.com
Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular
mechanisms and pathways under normal and pathological conditions. NO production, its …

Triterpenoids and meroterpenoids from the edible Ganoderma resinaceum and their potential anti-inflammatory, antioxidant and anti-apoptosis activities

RW Kou, B Xia, ZJ Wang, JN Li, JR Yang, YQ Gao… - Bioorganic …, 2022 - Elsevier
Ganoderma resinaceum, as a traditional edible mushroom, has been widely reported to
improve neurodegenerative diseases characterized by oxidative stress and inflammation. In …

[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease

J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

[HTML][HTML] In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity

A Ledo, E Fernandes, A Salvador, J Laranjinha… - Redox Biology, 2022 - Elsevier
Hydrogen peroxide is a major redox signaling molecule underlying a novel paradigm of cell
function and communication. A role for H 2 O 2 as an intercellular signaling molecule and …

Neuroprotective Activity of Melittin—The Main Component of Bee Venom—Against Oxidative Stress Induced by Aβ25–35 in In Vitro and In Vivo Models

CD Nguyen, G Lee - Antioxidants, 2021 - mdpi.com
Melittin, a 26-amino acid peptide, is the main component of the venom of four honeybee
species and exhibits neuroprotective actions. However, it is unclear how melittin ameliorates …

Disturbed balance of inhibitory signaling links hearing loss and cognition

M Knipper, W Singer, K Schwabe… - Frontiers in Neural …, 2022 - frontiersin.org
Neuronal hyperexcitability in the central auditory pathway linked to reduced inhibitory
activity is associated with numerous forms of hearing loss, including noise damage, age …

Bee Venom Activates the Nrf2/HO-1 and TrkB/CREB/BDNF Pathways in Neuronal Cell Responses against Oxidative Stress Induced by Aβ1–42

CD Nguyen, J Yoo, SY Hwang, SY Cho, M Kim… - International Journal of …, 2022 - mdpi.com
Honeybee venom has recently been considered an anti-neurodegenerative agent, primarily
due to its anti-inflammatory effects. The natural accumulation of amyloid-beta (Aβ) in the …

Carvacrol improved learning and memory and attenuated the brain tissue oxidative damage in aged male rats

MA Forqani, M Akbarian, S Amirahmadi… - International Journal …, 2023 - Taylor & Francis
Introduction: Aging is an unavoidable process in the body that is accompanied by impaired
tissue homeostasis and various changes. Carvacrol has attracted considerable attention for …

A high fat/cholesterol diet recapitulates some Alzheimer's disease-like features in mice: focus on hippocampal mitochondrial dysfunction

G Mancini, C Dias, CF Lourenco… - Journal of …, 2021 - content.iospress.com
Background: Ample evidence from clinical and pre-clinical studies suggests mid-life
hypercholesterolemia as a risk factor for developing Alzheimer's disease (AD) at a later age …