Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes
S Lykke-Andersen, TH Jensen - Nature reviews Molecular cell biology, 2015 - nature.com
Nonsense-mediated mRNA decay (NMD) is probably the best characterized eukaryotic RNA
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …
degradation pathway. Through intricate steps, a set of NMD factors recognize and degrade …
Biological plasticity rescues target activity in CRISPR knock outs
Gene knock outs (KOs) are efficiently engineered through CRISPR–Cas9-induced frameshift
mutations. While the efficiency of DNA editing is readily verified by DNA sequencing, a …
mutations. While the efficiency of DNA editing is readily verified by DNA sequencing, a …
Ribosome-associated protein quality control
O Brandman, RS Hegde - Nature structural & molecular biology, 2016 - nature.com
Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …
ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation
E Sundaramoorthy, M Leonard, R Mak, J Liao… - Molecular cell, 2017 - cell.com
Ribosomes that experience terminal stalls during translation are resolved by ribosome-
associated quality control (QC) pathways that oversee mRNA and nascent chain destruction …
associated quality control (QC) pathways that oversee mRNA and nascent chain destruction …
Alternative splicing may not be the key to proteome complexity
Alternative splicing is commonly believed to be a major source of cellular protein diversity.
However, although many thousands of alternatively spliced transcripts are routinely detected …
However, although many thousands of alternatively spliced transcripts are routinely detected …
The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis
H Meyer, CC Weihl - Journal of cell science, 2014 - journals.biologists.com
The ATPase valosin-containing protein (VCP)/p97 has emerged as a central and important
element of the ubiquitin system. Together with a network of cofactors, it regulates an ever …
element of the ubiquitin system. Together with a network of cofactors, it regulates an ever …
Codon usage and 3′ UTR length determine maternal mRNA stability in zebrafish
The control of mRNA stability plays a central role in regulating gene expression. In
metazoans, the earliest stages of development are driven by maternally supplied mRNAs …
metazoans, the earliest stages of development are driven by maternally supplied mRNAs …
Mechanism and regulation of the nonsense-mediated decay pathway
N Hug, D Longman, JF Cáceres - Nucleic acids research, 2016 - academic.oup.com
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
Nonsense-mediated mRNA decay: degradation of defective transcripts is only part of the story
F He, A Jacobson - Annual review of genetics, 2015 - annualreviews.org
Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mechanism that
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …
monitors cytoplasmic mRNA translation and targets mRNAs undergoing premature …