Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope
glycoprotein gp120 to the CD4 receptor and/or coreceptors such as CC chemokine receptor …

Background and Aims Cenicriviroc (CVC) is a C‐C chemokine receptors type 2 and 5 dual
antagonist under evaluation for treating liver fibrosis in adults with nonalcoholic …

Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver …

Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite
cells, these normally quiescent cells are induced to proliferate by wound-derived signals …

Background & Aims Interactions between CC chemokine receptor types 2 (CCR2) and 5
(CCR5) and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting …

Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure
(ALF) in humans and induces hepatocyte necrosis, followed by activation of the innate …

Kupffer cell and macrophage (MØ) activation contributes to steatosis, inflammation, and
fibrosis in alcoholic liver disease (ALD). We found increased frequency of MØ, T cells, and …

The prevalence of chronic viral infectious diseases, such as human immunodeficiency virus
(HIV), hepatitis C virus (HCV), and influenza virus; the emergence and re-emergence of new …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …