The complex relationship between virulence and antibiotic resistance

M Schroeder, BD Brooks, AE Brooks - Genes, 2017 - mdpi.com
Antibiotic resistance, prompted by the overuse of antimicrobial agents, may arise from a
variety of mechanisms, particularly horizontal gene transfer of virulence and antibiotic …

Mechanisms of DNA uptake by naturally competent bacteria

D Dubnau, M Blokesch - Annual review of genetics, 2019 - annualreviews.org
Transformation is a widespread mechanism of horizontal gene transfer in bacteria. DNA
uptake to the periplasmic compartment requires a DNA-uptake pilus and the DNA-binding …

Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans

E Shanker, MJ Federle - Genes, 2017 - mdpi.com
The human pathogens Streptococcus pneumoniae and Streptococcus mutans have both
evolved complex quorum sensing (QS) systems that regulate the production of bacteriocins …

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

J Slager, R Aprianto, JW Veening - Nucleic acids research, 2018 - academic.oup.com
A precise understanding of the genomic organization into transcriptional units and their
regulation is essential for our comprehension of opportunistic human pathogens and how …

Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence

S Moreno-Gámez, RA Sorg, A Domenech… - Nature …, 2017 - nature.com
Streptococcus pneumoniae becomes competent for genetic transformation when exposed to
an autoinducer peptide known as competence-stimulating peptide (CSP). This peptide was …

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria

JW Veening, M Blokesch - Nature Reviews Microbiology, 2017 - nature.com
Natural competence enables bacteria to take up exogenous DNA. The evolutionary function
of natural competence remains controversial, as imported DNA can act as a source of …

Bacteriocins: not only antibacterial agents

D Drider, F Bendali, K Naghmouchi… - Probiotics and …, 2016 - Springer
This commentary was aimed at shedding light on the multifunction of bacteriocins mainly
those produced by lactic acid bacteria. These antibacterial agents were first used to improve …

High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

R Aprianto, J Slager, S Holsappel… - Nucleic acids …, 2018 - academic.oup.com
Streptococcus pneumoniae is an opportunistic human pathogen that typically colonizes the
nasopharyngeal passage and causes lethal disease in other host niches, such as the lung …

Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions

S Rebuffat - Natural Product Reports, 2022 - pubs.rsc.org
It is currently well established that multicellular organisms live in tight association with
complex communities of microorganisms including a large number of bacteria. These are …

Streptococcus pneumoniae two-component regulatory systems: The interplay of the pneumococcus with its environment

A Gómez-Mejia, G Gámez, S Hammerschmidt - International Journal of …, 2018 - Elsevier
Streptococcus pneumoniae is a human pathobiont possessing a diverse array of
multifunctional proteins essential for bacterial fitness and virulence. Gene expression is …