MHC class II presentation in autoimmunity
IA Ishina, MY Zakharova, IN Kurbatskaia, AE Mamedov… - Cells, 2023 - mdpi.com
Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is
crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self …
crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self …
T cell receptor signaling in the differentiation and plasticity of CD4+ T cells
CD4+ T cells are critical components of the adaptive immune system. The T cell receptor
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …
(TCR) and co-receptor signaling cascades shape the phenotype and functions of CD4+ T …
Delayed graft rejection in autoimmune islet transplantation via biomaterial immunotherapy
The induction of operational immune tolerance is a major goal in beta-cell replacement
strategies for the treatment of type 1 diabetes. Our group previously reported long-term …
strategies for the treatment of type 1 diabetes. Our group previously reported long-term …
Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection
K Yang, Y Zhang, J Ding, Z Li, H Zhang… - Frontiers in …, 2024 - frontiersin.org
Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by pancreatic β cell
destruction and mediated primarily by autoreactive CD8+ T cells. It has been shown that …
destruction and mediated primarily by autoreactive CD8+ T cells. It has been shown that …
Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice
CL Ho, LT Yeh, YW Liu, JL Dong, HK Sytwu - bioRxiv, 2024 - biorxiv.org
Our understanding of autoimmune diabetes underscores the critical involvement of CD8+ T
cells recognizing islet-specific antigens. However, the influence of thymic positive selection …
cells recognizing islet-specific antigens. However, the influence of thymic positive selection …
[PDF][PDF] Spatial Analysis of High Parameter Imaging Data to Understand Early HIV-Cell Interactions in Colorectal Tissue
N Canete - 2023 - core.ac.uk
Abstract Although Human Immunodeficiency Virus (HIV) was first discovered over 30 years
ago, there remains no cure or vaccine for HIV. In Australia, HIV transmission almost …
ago, there remains no cure or vaccine for HIV. In Australia, HIV transmission almost …