[HTML][HTML] The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

COVID-19: A review of therapeutic strategies and vaccine candidates

V Izda, MA Jeffries, AH Sawalha - Clinical Immunology, 2021 - Elsevier
The world is engulfed by one of the most widespread and significant public health crises in
decades as COVID-19 has become among the leading causes of death internationally. The …

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

RW Paterson, RL Brown, L Benjamin, R Nortley… - Brain, 2020 - academic.oup.com
Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness …

Effect of tocilizumab vs standard care on clinical worsening in patients hospitalized with COVID-19 pneumonia: a randomized clinical trial

C Salvarani, G Dolci, M Massari, DF Merlo… - JAMA internal …, 2021 - jamanetwork.com
Importance The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of
people worldwide. Tocilizumab has shown promising results in retrospective studies in …

[HTML][HTML] Tocilizumab in patients hospitalized with Covid-19 pneumonia

C Salama, J Han, L Yau, WG Reiss… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background Coronavirus disease 2019 (Covid-19) pneumonia is often associated
with hyperinflammation. Despite the disproportionate incidence of Covid-19 among …

Association between early treatment with tocilizumab and mortality among critically ill patients with COVID-19

S Gupta, W Wang, SS Hayek, L Chan… - JAMA internal …, 2021 - jamanetwork.com
Importance Therapies that improve survival in critically ill patients with coronavirus disease
2019 (COVID-19) are needed. Tocilizumab, a monoclonal antibody against the interleukin 6 …

[HTML][HTML] Efficacy of tocilizumab in patients hospitalized with Covid-19

JH Stone, MJ Frigault, NJ Serling-Boyd… - … England Journal of …, 2020 - Mass Medical Soc
Background The efficacy of interleukin-6 receptor blockade in hospitalized patients with
coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is …

[PDF][PDF] COVID-19 and cancer: current challenges and perspectives

Z Bakouny, JE Hawley, TK Choueiri, S Peters, BI Rini… - Cancer cell, 2020 - cell.com
Patients with cancer have been disproportionately affected by the COVID-19 pandemic. This
effect has included the adverse outcomes in patients with cancer who develop COVID-19 …

[HTML][HTML] Use of ivermectin is associated with lower mortality in hospitalized patients with coronavirus disease 2019: the ivermectin in COVID nineteen study

JC Rajter, MS Sherman, N Fatteh, F Vogel, J Sacks… - Chest, 2021 - Elsevier
Background Ivermectin was shown to inhibit severe acute respiratory syndrome coronavirus
2 replication in vitro, which has led to off-label use, but clinical efficacy has not been …

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome
coronavirus 2 presents with a spectrum of clinical manifestations from asymptomatic or mild …