[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges

AD Singhi, EJ Koay, ST Chari, A Maitra - Gastroenterology, 2019 - Elsevier
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas

M Tanaka, C Fernández-del Castillo, T Kamisawa… - Pancreatology, 2017 - Elsevier
The management of intraductal papillary mucinous neoplasm (IPMN) continues to evolve. In
particular, the indications for resection of branch duct IPMN have changed from early …

European evidence-based guidelines on pancreatic cystic neoplasms

European Study Group on Cystic Tumours of the … - Gut, 2018 - gut.bmj.com
Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are
lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of …

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia

AD Singhi, K McGrath, RE Brand, A Khalid, HJ Zeh… - Gut, 2018 - gut.bmj.com
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the
evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for …

Diagnosis and management of pancreatic cystic neoplasms: current evidence and guidelines

NCM Van Huijgevoort, M Del Chiaro… - Nature reviews …, 2019 - nature.com
Pancreatic cystic neoplasms (PCN) are a heterogeneous group of pancreatic cysts that
include intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, serous cystic …

Cancer overdiagnosis: a biological challenge and clinical dilemma

S Srivastava, EJ Koay, AD Borowsky… - Nature Reviews …, 2019 - nature.com
For cancer screening to be successful, it should primarily detect cancers with lethal potential
or their precursors early, leading to therapy that reduces mortality and morbidity. Screening …

Prospective, multi-institutional, real-time next-generation sequencing of pancreatic cyst fluid reveals diverse genomic alterations that improve the clinical management …

A Paniccia, PM Polanco, BA Boone, AI Wald… - Gastroenterology, 2023 - Elsevier
Background & Aims Next-generation sequencing (NGS) of pancreatic cyst fluid is a useful
adjunct in the assessment of patients with pancreatic cyst. However, previous studies have …

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas

T Ohtsuka, C Fernandez-del Castillo, T Furukawa… - Pancreatology, 2023 - Elsevier
This study group aimed to revise the 2017 international consensus guidelines for the
management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas, and …

[HTML][HTML] Artificial intelligence and early detection of pancreatic cancer: 2020 summative review

B Kenner, ST Chari, D Kelsen, DS Klimstra, SJ Pandol… - Pancreas, 2021 - journals.lww.com
Despite considerable research efforts, pancreatic cancer is associated with a dire prognosis
and a 5-year survival rate of only 10%. Early symptoms of the disease are mostly …

Early detection of pancreatic cancer using DNA-based molecular approaches

AD Singhi, LD Wood - Nature Reviews Gastroenterology & Hepatology, 2021 - nature.com
Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …