[HTML][HTML] From purines to purinergic signalling: molecular functions and human diseases
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
[HTML][HTML] Targeting adenosine in cancer immunotherapy to enhance T-cell function
S Vigano, D Alatzoglou, M Irving… - Frontiers in …, 2019 - frontiersin.org
T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation
A Mousset, E Lecorgne, I Bourget, P Lopez, K Jenovai… - Cancer Cell, 2023 - cell.com
Metastasis is the major cause of cancer death, and the development of therapy resistance is
common. The tumor microenvironment can confer chemotherapy resistance …
common. The tumor microenvironment can confer chemotherapy resistance …
ATP‐responsive smart hydrogel releasing immune adjuvant synchronized with repeated chemotherapy or radiotherapy to boost antitumor immunity
L Sun, F Shen, L Tian, H Tao, Z Xiong, J Xu… - Advanced …, 2021 - Wiley Online Library
Certain chemotherapeutics and forms of ionizing radiation can induce immunogenic cell
death (ICD). If there simultaneously exist immune adjuvants within the tumor, such antitumor …
death (ICD). If there simultaneously exist immune adjuvants within the tumor, such antitumor …
[HTML][HTML] Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors
KM Heinhuis, W Ros, M Kok, N Steeghs, JH Beijnen… - Annals of …, 2019 - Elsevier
Background Cancer immunotherapy has changed the standard of care for a subgroup of
patients with advanced disease. Immune checkpoint blockade (ICB) in particular has shown …
patients with advanced disease. Immune checkpoint blockade (ICB) in particular has shown …
[HTML][HTML] Extracellular purines, purinergic receptors and tumor growth
F Di Virgilio, E Adinolfi - Oncogene, 2017 - nature.com
Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …
Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
[HTML][HTML] From immunogenic cell death to immunogenic modulation: select chemotherapy regimens induce a spectrum of immune-enhancing activities in the tumor …
Cancer treatment has rapidly entered the age of immunotherapy, and it is becoming clear
that the effective therapy of established tumors necessitates rational multi-combination …
that the effective therapy of established tumors necessitates rational multi-combination …
Consensus guidelines for the detection of immunogenic cell death
O Kepp, L Senovilla, I Vitale, E Vacchelli… - …, 2014 - Taylor & Francis
Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …
Immunogenic cell death and DAMPs in cancer therapy
Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …
death that did not trigger an immune response, in recent years a new concept of …