Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy

F Cofano, M Boido, M Monticelli, F Zenga… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

JM Griffin, F Bradke - EMBO molecular medicine, 2020 - embopress.org
The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis

D Karussis, C Karageorgiou… - Archives of …, 2010 - jamanetwork.com
Objective To evaluate the feasibility, safety, and immunological effects of intrathecal and
intravenous administration of autologous mesenchymal stem cells (MSCs)(also …

Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair—current views

DG Phinney, DJ Prockop - Stem cells, 2007 - academic.oup.com
Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow
of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the …

Fat tissue: an underappreciated source of stem cells for biotechnology

JK Fraser, I Wulur, Z Alfonso, MH Hedrick - Trends in biotechnology, 2006 - cell.com
Adipose tissue can be harvested in large amounts with minimal morbidity. It contains
numerous cells types, including adipocytes, preadipocytes, vascular endothelial cells and …

Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro

PJ Kingham, DF Kalbermatten, D Mahay… - Experimental …, 2007 - Elsevier
Experimentally, peripheral nerve repair can be enhanced by Schwann cell transplantation
but the clinical application is limited by donor site morbidity and the inability to generate a …

[HTML][HTML] Stem cell treatment of degenerative eye disease

B Mead, M Berry, A Logan, RAH Scott, W Leadbeater… - Stem cell …, 2015 - Elsevier
Stem cell therapies are being explored extensively as treatments for degenerative eye
disease, either for replacing lost neurons, restoring neural circuits or, based on more recent …

Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury

AM Parr, CH Tator, A Keating - Bone marrow transplantation, 2007 - nature.com
Transplantation of bone marrow-derived mesenchymal stromal cells (MSCs) into the injured
brain or spinal cord may provide therapeutic benefit. Several models of central nervous …

Mesenchymal stem cells for clinical application

L Sensebe, M Krampera, H Schrezenmeier… - Vox …, 2010 - Wiley Online Library
Mesenchymal Stem Cells/Multipotent Marrow Stromal Cells (MSC) are multipotent adult
stem cells present in all tissues, as part of the perivascular population. As multipotent cells …

BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury

P Lu, LL Jones, MH Tuszynski - Experimental neurology, 2005 - Elsevier
Bone marrow stromal cells (MSCs) constitute a heterogeneous cell layer in the bone
marrow, supporting the growth and differentiation of hematopoietic stem cells. Recently, it …