The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and
intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Therapeutic targeting the protein-protein interaction (PPI) of Nuclear factor (erythroid-
derived 2)-like 2 (Nrf2) and its main regulator, Kelch-like ECH-Associating protein 1 (Keap1) …

过量活性氧(reactive oxygen species, ROS) 造成的氧化应激日益成为人们迫切需要解决的问题
. 而由于化学合成抗氧化剂存在诸多缺陷, 人们逐渐将焦点转移至天然抗氧化剂 …

The oxidative stresses are a major insult in pulmonary injury such as acute lung injury (ALI)
and acute respiratory distress syndrome (ARDS), two clinical manifestations of acute …

Free energy perturbation (FEP) calculations are now routinely used in drug discovery to
estimate the relative FEB (RFEB) of small molecules to a biomolecular target of interest …

BACKGROUND Jiuzao is the residue after Bajiu distillation which is usually used as forage
for livestock. However, it is not fully utilized yet considering the content of protein remained …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of both upper and lower motor neurons in the brain and spinal cord. ALS is …

The breach of proteostasis, leading to the accumulation of protein aggregates, is a hallmark
of ageing and age-associated disorders, up to now well-established in neurodegeneration …