Maintenance of healthy human metabolism depends on a symbiotic consortium among
bacteria, archaea, viruses, fungi, and host eukaryotic cells throughout the human …

Immune cells constantly patrol the body via the bloodstream and migrate into multiple
tissues where they face variable and sometimes demanding environmental conditions …

The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …

Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients,
but a large proportion of cancers do not respond to ICT. To date, the genomic underpinnings …

Emerging evidence suggests that metabolic adaptation is a vital hallmark and prerequisite
for macrophage phenotype transition. Pyruvate kinase M2 (PKM2) is an essential molecular …

Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar
to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The …

Neutrophils rely predominantly on glycolytic metabolism for their biological functions,
including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) …

Mitochondria are cellular organelles essential for multiple biological processes, including
energy production, metabolites biosynthesis, cell death, and immunological responses …

There is a critical need for cerebro-protective interventions to improve the suboptimal
outcomes of patients with ischemic stroke who have been treated with reperfusion …

Sepsis is a systemic inflammatory response syndrome with high mortality and morbidity
worldwide. In this study, we demonstrate that capsaicin not only suppresses inflammation in …