The current therapy for depression is less than ideal with remission rates of only 25–35%
and a slow onset of action with other associated side effects. The persistence of anhedonia …

The serotonin transporter protein (SERT) has been the target for the development of several
modern antidepressants with an objective of achieving selectivity over other monoamine …

New arylthioindole derivatives having different cyclic substituents at position 2 of the indole
were synthesized as anticancer agents. Several compounds inhibited tubulin polymerization …

The 3C-like protease (3CLpro), which controls the severe acute respiratory syndrome
(SARS) coronavirus replication, has been identified as a potential target for drug design in …

In previous studies, the polycyclic cage amine 8-benzylamino-8, 11-oxapentacyclo [5.4.
0.02, 6.03, 10.05, 9] undecane (NGP1-01) and a number of its derivatives showed positive …

Ionic diamine rhodium complex (1) catalyzes the reductive N-cyclization of 2-
vinylnitroarenes using carbon monoxide as a reducing agent to afford functionalized …

The dopamine transporter (DAT) is a target for the development of pharmacotherapies for a
number of central disorders including Parkinson's disease, Alzheimer's disease …

A regiocontrolled synthesis of 3, 4-disubstituted pyrrole-2-carboxaldehydes was completed
in two steps from acyclic starting materials. A Barton− Zard pyrrole synthesis between N …

Heterocyclic compounds form largest classical division of organic chemistry by gaining
enormous importance in industry and biology.. The mainstream of pharmaceuticals is …

The reversible acetylation of histones is critical for regulation of eukaryotic gene expression.
The histone deacetylase inhibitors trichostatin (TSA, 1), MS-275 (2) and suberoylanilide …