The burden of human disease lies predominantly in polygenic diseases. Since the early
2000s, genome-wide association studies (GWAS) have identified genetic variants and loci …

Epigenetics, the inheritance of genomic information independent of DNA sequence, controls
the interpretation of extracellular and intracellular signals in cell homeostasis, proliferation …

Precise dissection of DNA–protein interactions is essential for elucidating the recognition
basis, dynamics and gene regulation mechanism. However, global profiling of weak and …

The cistrome consists of all cis-acting regulatory elements recognized by transcription
factors (TFs). However, only a portion of the cistrome is active for TF binding in a specific …

Protein− nucleic acid interactions, including the interac-tions of proteins with DNA, RNA, and
DNA/RNA hybrid, often confer important biological consequences to targeted nucleic acids …

Point mutations within the TERT promoter are the most recurrent somatic noncoding
mutations identified across different cancer types, including glioblastoma, melanoma …

Epigenetic regulation plays a pivotal role in various biological and disease processes. Two
key lines of investigation have been pursued that aim to unravel endogenous epigenetic …

Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over
the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately …

Borrelia burgdorferi, the etiological agent of Lyme disease, is the most prevalent vector-
borne disease in the United States. The spirochetal population is naturally maintained by …