Challenges and opportunities for developing more generalizable polygenic risk scores
Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …
diseases by aggregating information across multiple genetic variants identified from genome …
Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as …
technology has enabled the generation of new insights into the phenotype known as …
[HTML][HTML] Ultra-processed food intake in association with BMI change and risk of overweight and obesity: A prospective analysis of the French NutriNet-Santé cohort
Background Ultra-processed food (UPF) consumption has increased drastically worldwide
and already represents 50%–60% of total daily energy intake in several high-income …
and already represents 50%–60% of total daily energy intake in several high-income …
[HTML][HTML] Polygenic prediction of weight and obesity trajectories from birth to adulthood
Severe obesity is a rapidly growing global health threat. Although often attributed to
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …
Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications
MO Goodarzi - The lancet Diabetes & endocrinology, 2018 - thelancet.com
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although …
Deconstructing the sources of genotype-phenotype associations in humans
Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …
tremendous pace in recent decades. Most human traits have been shown to be affected by a …
[HTML][HTML] 10 years of GWAS discovery: biology, function, and translation
Application of the experimental design of genome-wide association studies (GWASs) is now
10 years old (young), and here we review the remarkable range of discoveries it has …
10 years old (young), and here we review the remarkable range of discoveries it has …
Genetic predisposition to high blood pressure and lifestyle factors: associations with midlife blood pressure levels and cardiovascular events
Background: High blood pressure (BP) is a major risk factor for cardiovascular diseases
(CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors …
(CVDs), the leading cause of mortality worldwide. Both heritable and lifestyle risk factors …
[HTML][HTML] Causes of obesity: a review
B Masood, M Moorthy - Clinical Medicine, 2023 - Elsevier
Obesity research is advancing swiftly, but the increase in obesity prevalence is faster. Over
the past three decades, researchers have found that biopsychosocial factors determine …
the past three decades, researchers have found that biopsychosocial factors determine …
[HTML][HTML] Socioeconomic inequalities in childhood and adolescent body-mass index, weight, and height from 1953 to 2015: an analysis of four longitudinal …
Background Socioeconomic inequalities in childhood body-mass index (BMI) have been
documented in high-income countries; however, uncertainty exists with regard to how they …
documented in high-income countries; however, uncertainty exists with regard to how they …