Mechanisms of mitochondrial iron-sulfur protein biogenesis

R Lill, SA Freibert - Annual review of biochemistry, 2020 - annualreviews.org
Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …

[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology

JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …

Iron–sulfur cluster biogenesis and trafficking in mitochondria

JJ Braymer, R Lill - Journal of Biological Chemistry, 2017 - ASBMB
The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage,
multicompartment process that is essential for a broad range of cellular functions, including …

[HTML][HTML] Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

DJR Lane, AM Merlot, MLH Huang, DH Bae… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Biosynthesis and function of posttranscriptional modifications of transfer RNAs

B El Yacoubi, M Bailly… - Annual review of …, 2012 - annualreviews.org
Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …

[HTML][HTML] The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

R Lill, B Hoffmann, S Molik, AJ Pierik… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Mitochondria play a key role in iron metabolism in that they synthesize heme, assemble iron–
sulfur (Fe/S) proteins, and participate in cellular iron regulation. Here, we review the latter …

[HTML][HTML] Reprint of: Iron/sulfur proteins biogenesis in prokaryotes: formation, regulation and diversity

B Roche, L Aussel, B Ezraty, P Mandin, B Py… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Iron/sulfur centers are key cofactors of proteins intervening in multiple conserved cellular
processes, such as gene expression, DNA repair, RNA modification, central metabolism and …

Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease

TA Rouault - Disease models & mechanisms, 2012 - journals.biologists.com
Iron-sulfur (Fe-S) clusters are ubiquitous cofactors composed of iron and inorganic sulfur.
They are required for the function of proteins involved in a wide range of activities, including …

Protein interactions in human pathogens revealed through deep learning

IR Humphreys, J Zhang, M Baek, Y Wang… - Nature …, 2024 - nature.com
Identification of bacterial protein–protein interactions and predicting the structures of these
complexes could aid in the understanding of pathogenicity mechanisms and developing …

Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex

MT Boniecki, SA Freibert, U Mühlenhoff, R Lill… - Nature …, 2017 - nature.com
Abstract Iron–sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular
functions including DNA maintenance, protein translation, and energy conversion. De novo …