[HTML][HTML] The role of ceramide and sphingosine-1-phosphate in Alzheimer's disease and other neurodegenerative disorders
K Czubowicz, H Jęśko, P Wencel, WJ Lukiw… - Molecular …, 2019 - Springer
Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
and S1P)—are signaling molecules serving as intracellular second messengers. Moreover …
Sphingolipids in Alzheimer's disease, how can we target them?
SM Crivelli, C Giovagnoni, L Visseren… - Advanced drug delivery …, 2020 - Elsevier
Altered levels of sphingolipids and their metabolites in the brain, and the related
downstream effects on neuronal homeostasis and the immune system, provide a framework …
downstream effects on neuronal homeostasis and the immune system, provide a framework …
[HTML][HTML] Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
B Gril, AN Paranjape, S Woditschka, E Hua… - Nature …, 2018 - nature.com
Brain metastases are devastating complications of cancer. The blood–brain barrier (BBB),
which protects the normal brain, morphs into an inadequately characterized blood–tumor …
which protects the normal brain, morphs into an inadequately characterized blood–tumor …
Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks
I Medugorac, A Graf, C Grohs, S Rothammer… - Nature …, 2017 - nature.com
The yak is remarkable for its adaptation to high altitude and occupies a central place in the
economies of the mountainous regions of Asia. At lower elevations, it is common to hybridize …
economies of the mountainous regions of Asia. At lower elevations, it is common to hybridize …
Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism
H Wu, X Wang, J Gao, S Liang, Y Hao, C Sun, W Xia… - Life sciences, 2017 - Elsevier
Aims To investigate the effect of FTY720 on the valproic acid (VPA) rat model of autism. Main
methods As an animal model of autism, we used intraperitoneal injection of VPA on …
methods As an animal model of autism, we used intraperitoneal injection of VPA on …
Neuroinflammation related to the blood–brain barrier and sphingosine‐1‐phosphate in a pre‐clinical model of periodontal diseases and depression in rats
D Martín‐Hernández, M Martínez… - Journal of Clinical …, 2023 - Wiley Online Library
Aim To explore the potential mechanisms of neuroinflammation (microglia, blood–brain
barrier [BBB] permeability, and the sphingosine‐1‐phosphate [S1P] pathways) resulting …
barrier [BBB] permeability, and the sphingosine‐1‐phosphate [S1P] pathways) resulting …
[HTML][HTML] The cross-talk between sphingolipids and insulin-like growth factor signaling: significance for aging and neurodegeneration
H Jęśko, A Stępień, WJ Lukiw, RP Strosznajder - Molecular Neurobiology, 2019 - Springer
Abstract Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide,
and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation …
and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation …
[HTML][HTML] Sphingosine 1-phosphate–A double edged sword in the brain
I Karunakaran, G van Echten-Deckert - Biochimica et Biophysica Acta (BBA …, 2017 - Elsevier
The physiological functions of sphingosine 1-phosphate (S1P) and its pathological roles in
various diseases are increasingly being elucidated. Particularly, a growing body of literature …
various diseases are increasingly being elucidated. Particularly, a growing body of literature …
Explore the Therapeutic Composition and Mechanism of Schisandra chinensis‐Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on …
J Chen, WQ Hao, C Zhang, MR Cui… - Oxidative Medicine …, 2022 - Wiley Online Library
Background. Alzheimer's disease places a heavy economic burden to healthcare systems
around the world. However, the effective treatments are still lacking. Traditional Chinese …
around the world. However, the effective treatments are still lacking. Traditional Chinese …
[HTML][HTML] Modulations of bioactive lipids and their receptors in postmortem Alzheimer's disease brains
M Kurano, Y Saito, B Uranbileg, D Saigusa… - Frontiers in Aging …, 2022 - frontiersin.org
Background Analyses of brain samples from Alzheimer's disease (AD) patients may be
expected to help us improve our understanding of the pathogenesis of AD. Bioactive lipids …
expected to help us improve our understanding of the pathogenesis of AD. Bioactive lipids …