Anti-trypanosomatid drug discovery: progress and challenges
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …
Challenges and recent progress in drug discovery for tropical diseases
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …
impose a heavy economic burden on affected countries. These diseases predominantly …
An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases
V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …
leishmaniases span worldwide and therefore their impact is a universal concern. The …
Trypanosomes as a magnifying glass for cell and molecular biology
Abstract The African trypanosome, Trypanosoma brucei, has developed into a flexible and
robust experimental model for molecular and cellular parasitology, allowing us to better …
robust experimental model for molecular and cellular parasitology, allowing us to better …
Innovation in neglected tropical disease drug discovery and development
HB Weng, HX Chen, MW Wang - Infectious diseases of poverty, 2018 - mednexus.org
Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …
over a billion people in developing countries. The unmet treatment needs cause high …
Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …
a considerable global challenge. Despite the huge number of people infected, NDs do not …
[HTML][HTML] Drug discovery for chagas disease: A viewpoint
JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
[HTML][HTML] The translational challenge in Chagas disease drug development
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …
Targeting trypanothione reductase, a key enzyme in the redox trypanosomatid metabolism, to develop new drugs against leishmaniasis and trypanosomiases
The protozoans Leishmania and Trypanosoma, belonging to the same Trypanosomatidae
family, are the causative agents of Leishmaniasis, Chagas disease, and human African …
family, are the causative agents of Leishmaniasis, Chagas disease, and human African …